PRKAR1A

Across TCGA pan-cancer cohorts, PRKAR1A Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PRKAR1A data layer compared with 22 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PRKAR1A Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PRKAR1A expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

HNSC, UCEC, and BRCA are the cancer types where PRKAR1A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	0.087	0.756	<.001	34	view →
UCEC	DFS	Median	II,III,IV	1.000	0.433	.006	32	view →
BRCA	DFS	Median	All	0.558	0.903	<.001	18	view →
PCPG	OS	Median	All	0.009	0.946	<.001	12	view →
LGG	OS	Median	All	0.240	0.830	<.001	12	view →
ACC	DFS	Median	All	0.210	0.599	.029	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PRKAR1A–HNSC (OS)

Open the HNSC breakdown →