PRKAR1A

Across TCGA pan-cancer cohorts, PRKAR1A RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of PRKAR1A’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where PRKAR1A RNA is repressed in tumor relative to normal tissue. In most cancer types PRKAR1A is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.

KICH, LUSC, and UCEC are the cancer types where PRKAR1A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PRKAR1A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	All	−1.007	<.001	7	view →
LUSC	All	II,III,IV	−0.740	<.001	7	view →
UCEC	All	All	−1.367	<.001	6	view →
KIRC	Male	III,IV	−0.425	.002	6	view →
LUAD	All	All	−0.281	<.001	6	view →
CHOL	All	All	+1.132	<.001	5	view →
LIHC	All	All	+0.488	<.001	4	view →
ESCA	Female	All	+1.246	.010	2	view →
THCA	Male	II,III,IV	−0.303	.025	2	view →
HNSC	All	All	+0.251	.026	2	view →
PRAD	All	All	−0.216	.029	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

PRKAR1A–KICH

Open the KICH breakdown →