PRKAR1A

Across TCGA pan-cancer cohorts, PRKAR1A mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated PRKAR1A data layer compared with 22 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher PRKAR1A mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated PRKAR1A expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

PDAC, HNSC, and LUAD are the cancer types where PRKAR1A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	All	0.479	0.267	<.001	53	view →
HNSC	DFS	Quartile	II,III,IV	0.557	0.839	.013	3	view →
LUAD	OS	Quartile	II,III,IV	0.278	0.652	.005	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

PRKAR1A–PDAC (OS)

Open the PDAC breakdown →