PRKAR1A

Across TCGA patient cohorts, PRKAR1A RNA expression is significantly associated with the protein abundance of many other proteins, with 10,926 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible PRKAR1A-associated proteins across cancer lineages are EIF2S1, EIF2S2, and TPPP3. Each is linked with PRKAR1A in more than 4 cancer types. Because this analysis shows association rather than direction, both PRKAR1A-to-partner and partner-to-PRKAR1A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PRKAR1A versus EIF2S1 in BRCA, with a Pearson correlation of -0.27.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKAR1A→partner) and Y-score (partner→PRKAR1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	EIF2S1 →	-0.171	-0.627	.002	.002	3	4
BRCA	EIF2S2 →	-0.187	-0.775	.001	<.001	3	4
GBM	TPPP3 →	+1.001	+0.326	.001	.003	2	5
BRCA	RPL4 →	-0.417	-0.771	<.001	<.001	3	4
BRCA	RPL7 →	-0.393	-0.869	<.001	<.001	3	4
CCRCC	RPS2 →	-0.281	-0.306	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,926 associations by consensus.

PRKAR1A vs EIF2S1 — BRCA

Explore this scatter interactively →