PRKAG2

Across TCGA patient cohorts, PRKAG2 mutation is significantly associated with the RNA expression of many other genes, with 3,992 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRKAG2-associated genes across cancer lineages are RN7SL98P, RNU6-1038P, and RNA5SP105. Each is linked with PRKAG2 in more than 3 cancer types. Because this analysis shows association rather than direction, both PRKAG2-to-partner and partner-to-PRKAG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL98P grouped by PRKAG2-low versus PRKAG2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKAG2→partner) and Y-score (partner→PRKAG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL98P →	+0.081	+1.845	.001	.004	3	4
STAD	RNU6-1038P →	+0.738	+3.853	.005	.008	3	3
KIRP	RNA5SP105 →	+0.512	+4.943	<.001	.003	3	3
KIRP	PIGPP4 →	+0.162	+4.518	.003	.006	3	3
LUSC	SOCS2P1 →	+0.129	+6.438	<.001	.001	3	3
SKCM	SNORD90 →	+0.111	+2.628	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,992 associations by consensus.

RN7SL98P by PRKAG2 expression — UCEC

Explore this box plot interactively →