PRKAG2-AS1

Across TCGA pan-cancer cohorts, PRKAG2-AS1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of PRKAG2-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where PRKAG2-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types PRKAG2-AS1 is over-expressed in tumor, although a few such as KICH and BLCA show the opposite, repressed pattern.

KICH, BLCA, and THCA are the cancer types where PRKAG2-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PRKAG2-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	III,IV	−2.331	<.001	11	view →
BLCA	Male	IV	−2.137	<.001	11	view →
THCA	Male	All	−0.972	<.001	10	view →
KIRC	All	III,IV	+0.550	<.001	10	view →
COAD	All	All	−0.626	.001	7	view →
BRCA	All	II,III,IV	−0.807	<.001	6	view →
HNSC	Male	II,III,IV	−0.736	<.001	6	view →
KIRP	All	All	−0.634	<.001	6	view →
READ	All	II,III,IV	−1.932	.005	3	view →
CHOL	All	All	−0.897	<.001	3	view →
LUSC	All	II,III,IV	−0.461	.031	2	view →
LIHC	Female	II,III,IV	−0.754	.039	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

PRKAG2-AS1–KICH

Open the KICH breakdown →