PRKACG

Across TCGA patient cohorts, PRKACG mutation is significantly associated with the RNA expression of many other genes, with 2,103 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRKACG-associated genes across cancer lineages are MRPL37, DNAJC8, and CDCA8. Each is linked with PRKACG in more than 2 cancer types. Because this analysis shows association rather than direction, both PRKACG-to-partner and partner-to-PRKACG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPL37 grouped by PRKACG-low versus PRKACG-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKACG→partner) and Y-score (partner→PRKACG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MRPL37 →	+0.489	+2.828	<.001	.001	3	3
SKCM	DNAJC8 →	+0.405	+3.484	.003	.002	3	3
UCEC	CDCA8 →	+0.601	+2.823	.009	.001	3	3
SKCM	BUB3 →	+0.463	+1.771	.001	.008	3	3
SKCM	BOLA3 →	+0.403	+3.597	.001	.001	3	3
UCEC	ZCCHC17 →	+0.307	+2.001	.004	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,103 associations by consensus.

MRPL37 by PRKACG expression — UCEC

Explore this box plot interactively →