PRKACG

Across TCGA pan-cancer cohorts, PRKACG RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of PRKACG’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PRKACG RNA is repressed in tumor relative to normal tissue. In most cancer types PRKACG is over-expressed in tumor, although a few such as KIRC and PRAD show the opposite, repressed pattern.

KIRC, STAD, and PRAD are the cancer types where PRKACG tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PRKACG RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	−0.017	.008	5	view →
STAD	All	All	+0.078	.001	4	view →
PRAD	All	All	−0.020	.017	2	view →
READ	All	All	−0.032	.026	1	view →
KICH	All	IV	−0.032	.026	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

PRKACG–KIRC

Open the KIRC breakdown →