PRKACG

Across TCGA patient cohorts, PRKACG mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRKACG-associated genes across cancer lineages are Annexin-1, Caspase-7-cleavedD198, and FoxM1. Each is linked with PRKACG in more than 2 cancer types. Because this analysis shows association rather than direction, both PRKACG-to-partner and partner-to-PRKACG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by PRKACG-low versus PRKACG-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKACG→partner) and Y-score (partner→PRKACG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.741	+3.604	<.001	.001	3	3
COAD	Caspase-7-cleavedD198 →	+1.621	+2.815	<.001	.036	3	3
UCEC	FoxM1 →	+0.208	+1.584	.040	.036	3	2
SKCM	PCNA →	+0.258	+3.169	.001	.017	3	2
SKCM	Smad4 →	+0.126	+2.493	.006	.009	3	2
UCEC	STAT3_pY705 →	-0.305	-1.584	.003	.036	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

Annexin-1 by PRKACG expression — UCEC

Explore this box plot interactively →