PRKACG

Across TCGA cell cohorts, PRKACG RNA expression is significantly associated with the go_rna of many other GO terms, with 281 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PRKACG-associated GO terms across cancer lineages are Membrane depolarization during action potential, Cardiac conduction, and Regulation of heart rate by cardiac conduction. Each is linked with PRKACG in more than 2 cancer types. Because this analysis shows association rather than direction, both PRKACG-to-partner and partner-to-PRKACG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Membrane depolarization during action potential grouped by PRKACG-low versus PRKACG-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKACG→partner) and Y-score (partner→PRKACG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Membrane depolarization during action potential →	+0.128	+0.016	<.001	.006	3	3
BLOOD_Leukemia	Cardiac conduction →	+0.046	+0.021	<.001	.005	3	3
BLOOD_Leukemia	Regulation of heart rate by cardiac conduction →	+0.122	+0.031	<.001	.005	3	3
BLOOD_Lymphoma	Maturation of 5.8S rRNA →	+0.078	+0.009	<.001	.007	2	3
BLOOD_Lymphoma	Regulation of DNA strand elongation →	+0.058	+0.009	<.001	.006	3	2
LARGE_INTESTINE	Beige fat cell differentiation →	+0.162	+0.023	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 281 associations by consensus.

Membrane depolarization during action potential by PRKACG expression — LARGE_INTESTINE

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