PRKACG

Across TCGA cell cohorts, PRKACG mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible PRKACG-associated genes across cancer lineages are PPIAL4D, CD1C, and TIFAB. Each is linked with PRKACG in more than 1 cancer types. Because this analysis shows association rather than direction, both PRKACG-to-partner and partner-to-PRKACG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPIAL4D grouped by PRKACG-low versus PRKACG-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKACG→partner) and Y-score (partner→PRKACG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PPIAL4D →	+0.094	+3.747	.008	.008	3	2
SKIN	CD1C →	+0.066	+4.054	<.001	.004	3	1
LARGE_INTESTINE	TIFAB →	+0.006	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

PPIAL4D by PRKACG expression — SKIN

Explore this box plot interactively →