PRKACB

Across TCGA patient cohorts, PRKACB protein abundance is significantly associated with the RNA expression of many other genes, with 18,026 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PRKACB-associated genes across cancer lineages are PLCL1, EIF5A, and KCNN3. Each is linked with PRKACB in more than 5 cancer types. Because this analysis shows association rather than direction, both PRKACB-to-partner and partner-to-PRKACB results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PRKACB versus PLCL1 in GBM, with a Pearson correlation of 0.45.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKACB→partner) and Y-score (partner→PRKACB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PLCL1 →	+1.076	+0.335	<.001	<.001	3	6
COAD	EIF5A →	-0.654	-0.386	.001	.003	3	6
GBM	KCNN3 →	+1.030	+0.326	<.001	<.001	3	6
GBM	HMGCLL1 →	+0.746	+0.346	<.001	<.001	3	6
COAD	SAMD13 →	+0.677	+0.399	<.001	<.001	3	6
GBM	DUSP26 →	+1.320	+0.365	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,026 associations by consensus.

PRKACB vs PLCL1 — GBM

Explore this scatter interactively →