PRKACB

Across TCGA pan-cancer cohorts, PRKACB RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of PRKACB’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PRKACB RNA is repressed in tumor relative to normal tissue. In most cancer types PRKACB is over-expressed in tumor, although a few such as COAD and THCA show the opposite, repressed pattern.

COAD, THCA, and LUSC are the cancer types where PRKACB tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PRKACB RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	−2.635	<.001	11	view →
THCA	Male	III,IV	−2.055	<.001	10	view →
LUSC	All	II,III,IV	−0.764	<.001	7	view →
KIRC	All	III,IV	−0.373	<.001	7	view →
KICH	All	All	−0.934	<.001	6	view →
READ	All	All	−2.512	<.001	5	view →
HNSC	Female	III,IV	+1.179	.002	3	view →
CHOL	Female	All	+1.356	<.001	2	view →
UCEC	All	All	−1.021	<.001	2	view →
LIHC	Male	All	+0.461	.018	2	view →
LUAD	Male	II,III,IV	+0.445	.026	2	view →
LUAD	Female	II,III,IV	−0.511	.014	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 11 lineages.

PRKACB–COAD

Open the COAD breakdown →