PRKACB

Across TCGA patient cohorts, PRKACB mutation is significantly associated with the RNA expression of many other genes, with 4,053 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRKACB-associated genes across cancer lineages are RPL5P21, RPL32P14, and FAM230A. Each is linked with PRKACB in more than 2 cancer types. Because this analysis shows association rather than direction, both PRKACB-to-partner and partner-to-PRKACB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL5P21 grouped by PRKACB-low versus PRKACB-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKACB→partner) and Y-score (partner→PRKACB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RPL5P21 →	+0.034	+5.408	<.001	.002	3	3
ESCA	RPL32P14 →	+0.252	+5.450	<.001	.004	3	3
ESCA	FAM230A →	+0.018	+5.247	<.001	.006	3	3
BRCA	MIR7159 →	+0.476	+5.317	<.001	.006	3	2
ESCA	MIR548AD →	+0.538	+5.681	<.001	.003	3	2
BLCA	PDE4DIPP5 →	+0.056	+3.892	.008	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,053 associations by consensus.

RPL5P21 by PRKACB expression — SKCM

Explore this box plot interactively →