PRKACB

Across TCGA cell cohorts, PRKACB mutation is significantly associated with the RNA expression of many other genes, with 1 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible PRKACB-associated genes across cancer lineages are TOPAZ1. Each is linked with PRKACB in more than 1 cancer types. Because this analysis shows association rather than direction, both PRKACB-to-partner and partner-to-PRKACB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TOPAZ1 grouped by PRKACB-low versus PRKACB-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKACB→partner) and Y-score (partner→PRKACB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	TOPAZ1 →	+0.166	+5.357	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 1 strongest of 1 associations by consensus.

TOPAZ1 by PRKACB expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →