PRKAA1

Across TCGA pan-cancer cohorts, PRKAA1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PRKAA1 data layer compared with 22 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PRKAA1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PRKAA1 expression acts as an unfavorable survival marker.

HNSC, PDAC, and CCRCC are the cancer types where PRKAA1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.291	1.000	.001	30	view →
PDAC	DFS	Median	IV	0.250	0.934	.024	11	view →
CCRCC	DFS	Median	All	0.619	0.863	.002	7	view →
LUAD	DFS	Tertile	II,III,IV	0.366	0.782	.020	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PRKAA1–HNSC (DFS)

Open the HNSC breakdown →