PRKAA1

Across TCGA cell cohorts, PRKAA1 mutation is significantly associated with the RNA expression of many other genes, with 162 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PRKAA1-associated genes across cancer lineages are HTN1, IL22, and CRYBA4. Each is linked with PRKAA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRKAA1-to-partner and partner-to-PRKAA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HTN1 grouped by PRKAA1-low versus PRKAA1-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKAA1→partner) and Y-score (partner→PRKAA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	HTN1 →	+0.109	+4.312	<.001	.001	3	2
BREAST	IL22 →	+0.048	+4.415	<.001	.001	3	1
BREAST	CRYBA4 →	+0.077	+3.691	.003	.009	3	1
BREAST	OR2S2 →	+0.101	+4.614	<.001	<.001	3	1
LUNG_NSCLC_LUAD	OR10K2 →	+0.012	+5.266	<.001	.001	3	1
LARGE_INTESTINE	CCDC134 →	+0.709	+3.212	.006	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 162 associations by consensus.

HTN1 by PRKAA1 expression — BREAST

Explore this box plot interactively →