PRIMA1

Across TCGA pan-cancer cohorts, PRIMA1 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated PRIMA1 data layer compared with 22 for mass-spec protein.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher PRIMA1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PRIMA1 expression acts as an unfavorable survival marker.

STAD and UCEC are the cancer types where PRIMA1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	OS	Median	II,III,IV	0.183	0.677	.004	24	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

PRIMA1–STAD (OS)

Open the STAD breakdown →