PRICKLE3

Across TCGA pan-cancer cohorts, PRICKLE3 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PRICKLE3 data layer compared with 23 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher PRICKLE3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PRICKLE3 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

LUAD, GBM, and HNSC are the cancer types where PRICKLE3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	All	0.524	0.867	.004	9	view →
GBM	OS	Tertile	All	0.813	1.000	.009	8	view →
HNSC	OS	Tertile	IV	1.000	0.469	.014	7	view →
LSCC	DFS	Median	II,III,IV	0.879	0.686	.012	5	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PRICKLE3–LUAD (DFS)

Open the LUAD breakdown →