PRICKLE2-DT

Across TCGA pan-cancer cohorts, PRICKLE2-DT RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated PRICKLE2-DT data layer.

The strongest signal is observed in mesothelioma (MESO), where higher PRICKLE2-DT RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PRICKLE2-DT expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUAD show a favorable association.

MESO, ACC, and UCEC are the cancer types where PRICKLE2-DT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Tertile	All	0.348	0.671	<.001	90	view →
ACC	OS	Tertile	All	0.151	0.727	<.001	57	view →
UCEC	OS	Quartile	II,III,IV	0.941	0.814	.002	56	view →
THCA	DFS	Quartile	II,III,IV	0.540	0.804	<.001	50	view →
STAD	DFS	Median	All	0.626	0.789	.012	23	view →
KIRC	DFS	Quartile	All	0.538	0.729	.007	21	view →
THYM	OS	Tertile	III,IV	0.229	1.000	<.001	18	view →
LAML	DFS	Tertile	All	0.231	0.577	.036	18	view →
LUAD	DFS	Quartile	III,IV	0.838	0.584	.004	15	view →
LGG	OS	Tertile	All	0.741	0.855	.019	10	view →
UVM	OS	Tertile	III,IV	0.223	0.709	.045	9	view →
READ	DFS	Quartile	III,IV	0.489	0.838	.017	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

PRICKLE2-DT–MESO (OS)

Open the MESO breakdown →