PRICKLE2-DT

Across TCGA pan-cancer cohorts, PRICKLE2-DT RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of PRICKLE2-DT’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PRICKLE2-DT RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PRICKLE2-DT is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.

HNSC, BRCA, and COAD are the cancer types where PRICKLE2-DT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PRICKLE2-DT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	II,III,IV	+0.222	<.001	11	view →
BRCA	All	III,IV	+0.435	<.001	8	view →
COAD	All	II,III,IV	+0.166	.001	7	view →
BLCA	All	All	+0.183	.003	6	view →
STAD	Male	All	+0.182	.006	5	view →
LUAD	All	II,III,IV	+0.255	.010	4	view →
LIHC	All	All	+0.038	.007	3	view →
THCA	All	All	+0.033	.020	3	view →
UCEC	All	All	+0.796	.028	2	view →
KICH	All	All	−0.090	.029	2	view →
LUSC	Male	III,IV	−0.460	.004	1	view →
STAD	Female	III,IV	−0.354	.036	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

PRICKLE2-DT–HNSC

Open the HNSC breakdown →