PRICKLE2-AS2

Across TCGA pan-cancer cohorts, PRICKLE2-AS2 RNA is linked to patient survival in 14 of 34 cancer types, making it the most broadly survival-associated PRICKLE2-AS2 data layer.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher PRICKLE2-AS2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PRICKLE2-AS2 expression acts as an unfavorable survival marker, although some lineages such as BRCA and LGG show a favorable association.

CESC, BRCA, and READ are the cancer types where PRICKLE2-AS2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Tertile	II,III,IV	0.571	0.808	.016	84	view →
BRCA	OS	Median	All	0.982	0.946	<.001	80	view →
READ	OS	Tertile	II,III,IV	0.252	0.864	<.001	78	view →
LGG	OS	Median	All	0.875	0.750	<.001	39	view →
LUAD	DFS	Median	All	0.419	0.271	.002	35	view →
COAD	OS	Tertile	II,III,IV	0.383	0.572	.026	27	view →
UCS	OS	Tertile	II,III,IV	0.840	0.317	.022	24	view →
UCEC	DFS	Tertile	All	0.425	0.722	.006	18	view →
SKCM	DFS	Tertile	IV	0.159	0.511	.020	18	view →
THCA	OS	Quartile	II,III,IV	0.940	0.988	.003	15	view →
ESCA	OS	Median	All	1.000	0.670	.026	3	view →
THYM	DFS	Tertile	All	1.000	0.713	.049	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

PRICKLE2-AS2–CESC (DFS)

Open the CESC breakdown →