PRICKLE2-AS2

Across TCGA pan-cancer cohorts, PRICKLE2-AS2 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of PRICKLE2-AS2’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where PRICKLE2-AS2 RNA is repressed in tumor relative to normal tissue. In most cancer types PRICKLE2-AS2 is over-expressed in tumor, although a few such as LUSC and THCA show the opposite, repressed pattern.

LUSC, THCA, and READ are the cancer types where PRICKLE2-AS2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PRICKLE2-AS2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Male	III,IV	−0.590	<.001	8	view →
THCA	Female	All	−0.270	<.001	5	view →
READ	All	III,IV	−0.315	.029	4	view →
BLCA	All	All	−0.183	.005	4	view →
COAD	All	II,III,IV	−0.062	.020	4	view →
LUAD	All	III,IV	−0.205	.011	3	view →
STAD	Female	All	−0.392	.015	2	view →
BRCA	All	III,IV	−0.243	.006	2	view →
HNSC	Male	All	−0.055	.029	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

PRICKLE2-AS2–LUSC

Open the LUSC breakdown →