PRG4

Across TCGA pan-cancer cohorts, PRG4 Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated PRG4 data layer compared with 21 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher PRG4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PRG4 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

THYM, CESC, and UCEC are the cancer types where PRG4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	All	0.604	0.967	<.001	39	view →
CESC	OS	Median	III,IV	0.068	0.756	<.001	18	view →
UCEC	DFS	Median	All	0.922	0.621	.014	10	view →
BLCA	OS	Median	IV	0.153	0.599	.018	9	view →
KIRP	DFS	Median	All	0.589	0.857	.035	6	view →
KIRC	OS	Median	All	0.249	0.810	.011	6	view →
ESCA	OS	Median	II,III,IV	0.295	0.707	.006	6	view →
LUSC	OS	Median	III,IV	0.285	0.683	.002	6	view →
STAD	OS	Median	III,IV	0.184	0.641	.011	6	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →
LGG	DFS	Median	All	0.171	0.826	.001	3	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

PRG4–THYM (OS)

Open the THYM breakdown →