PRG4

Across TCGA pan-cancer cohorts, PRG4 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of PRG4’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where PRG4 RNA is repressed in tumor relative to normal tissue. In most cancer types PRG4 is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

LUAD, LUSC, and LIHC are the cancer types where PRG4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PRG4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	III,IV	−3.092	<.001	11	view →
LUSC	Female	II,III,IV	−3.745	<.001	8	view →
LIHC	All	II,III,IV	−2.217	<.001	8	view →
HNSC	Male	II,III,IV	−1.102	.007	7	view →
BRCA	All	III,IV	−1.988	<.001	6	view →
UCEC	All	All	−0.653	.011	6	view →
CHOL	Female	All	−6.256	<.001	5	view →
KICH	Male	II,III,IV	−0.137	<.001	4	view →
BLCA	Male	All	−0.959	.011	3	view →
THCA	All	All	−0.196	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

PRG4–LUAD

Open the LUAD breakdown →