PRG4

Across TCGA patient cohorts, PRG4 mutation is significantly associated with the total protein of many other genes, with 71 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRG4-associated genes across cancer lineages are Cyclin-B1, ATM, and STAT3_pY705. Each is linked with PRG4 in more than 4 cancer types. Because this analysis shows association rather than direction, both PRG4-to-partner and partner-to-PRG4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by PRG4-low versus PRG4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRG4→partner) and Y-score (partner→PRG4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.622	+1.807	<.001	<.001	3	5
UCEC	ATM →	-0.519	-1.807	<.001	<.001	3	4
UCEC	STAT3_pY705 →	-0.336	-1.706	<.001	.003	3	3
LUAD	VHL →	-1.005	-3.000	.007	.034	3	3
COAD	ASNS →	+0.732	+3.008	<.001	.019	3	3
COAD	Caspase-7-cleavedD198 →	+1.000	+3.008	.014	.019	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 71 associations by consensus.

Cyclin-B1 by PRG4 expression — UCEC

Explore this box plot interactively →