PRG4

Across TCGA cell cohorts, PRG4 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,494 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PRG4-associated GO terms across cancer lineages are Subtelomeric heterochromatin formation, Positive regulation of DNA metabolic process, and Spindle assembly. Each is linked with PRG4 in more than 7 cancer types. Because this analysis shows association rather than direction, both PRG4-to-partner and partner-to-PRG4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Subtelomeric heterochromatin formation grouped by PRG4-low versus PRG4-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRG4→partner) and Y-score (partner→PRG4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Subtelomeric heterochromatin formation →	+0.105	+0.106	<.001	.001	3	8
LARGE_INTESTINE	Positive regulation of DNA metabolic process →	+0.050	+0.078	<.001	<.001	3	8
BLOOD_Leukemia	Spindle assembly →	+0.054	+0.135	<.001	.005	2	8
LARGE_INTESTINE	Host-mediated activation of viral transcription →	+0.080	+0.047	.002	.002	3	7
LARGE_INTESTINE	Mitotic DNA damage checkpoint signaling →	+0.053	+0.049	<.001	<.001	3	7
BLOOD_Leukemia	Positive regulation of DNA recombination →	+0.068	+0.109	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,494 associations by consensus.

Subtelomeric heterochromatin formation by PRG4 expression — BLOOD_Leukemia

Explore this box plot interactively →