PRG4

Across TCGA cell cohorts, PRG4 mutation is significantly associated with the RNA expression of many other genes, with 117 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PRG4-associated genes across cancer lineages are BBOX1, TMEM178B, and C6. Each is linked with PRG4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRG4-to-partner and partner-to-PRG4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BBOX1 grouped by PRG4-low versus PRG4-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRG4→partner) and Y-score (partner→PRG4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	BBOX1 →	+0.899	+4.083	<.001	.001	3	2
BLOOD_Leukemia	TMEM178B →	+0.535	+3.409	<.001	.008	3	2
BLOOD_Leukemia	C6 →	+0.083	+3.507	<.001	.004	3	2
LARGE_INTESTINE	STK33 →	+1.181	+3.160	<.001	.006	3	2
OESOPHAGUS	SOX3 →	+0.059	+4.017	<.001	.007	3	1
OESOPHAGUS	PTPRT →	+0.032	+4.392	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 117 associations by consensus.

BBOX1 by PRG4 expression — BLOOD_Leukemia

Explore this box plot interactively →