PRG3

Across TCGA patient cohorts, PRG3 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,368 significant associations in total. STAD shows the largest number of these associations.

The most reproducible PRG3-associated GO terms across cancer lineages are Positive regulation of translation, Regulation of cysteine-type endopeptidase activity involved in apoptotic process, and Respiratory system development. Each is linked with PRG3 in more than 10 cancer types. Because this analysis shows association rather than direction, both PRG3-to-partner and partner-to-PRG3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of translation grouped by PRG3-low versus PRG3-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRG3→partner) and Y-score (partner→PRG3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Positive regulation of translation →	+0.083	+0.145	<.001	<.001	3	11
STAD	Regulation of cysteine-type endopeptidase activity involved in apoptotic process →	+0.076	+0.152	<.001	<.001	3	10
STAD	Respiratory system development →	+0.059	+0.140	<.001	<.001	3	10
STAD	Amino acid metabolic process →	+0.055	+0.167	<.001	<.001	3	10
STAD	Nucleoside triphosphate biosynthetic process →	+0.092	+0.145	<.001	<.001	3	10
STAD	Aerobic respiration →	+0.098	+0.155	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,368 associations by consensus.

Positive regulation of translation by PRG3 expression — STAD

Explore this box plot interactively →