PRG3

Across TCGA pan-cancer cohorts, PRG3 RNA is linked to patient survival in 10 of 34 cancer types, making it the most broadly survival-associated PRG3 data layer compared with 2 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher PRG3 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PRG3 expression acts as an unfavorable survival marker.

LUSC, BLCA, and READ are the cancer types where PRG3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Tertile	IV	0.001	0.673	.014	72	view →
BLCA	DFS	Tertile	III,IV	0.125	0.332	.010	30	view →
READ	DFS	Tertile	All	0.111	0.799	.001	27	view →
MESO	OS	Tertile	IV	0.077	0.592	.019	18	view →
GBM	DFS	Tertile	All	0.069	0.292	<.001	18	view →
KIRC	DFS	Tertile	All	0.486	0.701	.005	16	view →
ACC	OS	Tertile	All	0.506	0.811	.040	9	view →
PAAD	DFS	Tertile	II,III,IV	0.280	0.464	.013	9	view →
ESCA	DFS	Tertile	All	0.370	0.880	.006	6	view →
KICH	DFS	Tertile	All	0.327	0.857	.033	3	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

PRG3–LUSC (OS)

Open the LUSC breakdown →