PRG3

Across TCGA patient cohorts, PRG3 protein abundance is significantly associated with the RNA expression of many other genes, with 7,800 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PRG3-associated genes across cancer lineages are CLC, CLEC10A, and CTSG. Each is linked with PRG3 in more than 6 cancer types. Because this analysis shows association rather than direction, both PRG3-to-partner and partner-to-PRG3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PRG3 versus CLC in LSCC, with a Pearson correlation of 0.83.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRG3→partner) and Y-score (partner→PRG3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CLC →	+1.787	+1.113	<.001	<.001	3	7
HNSC	CLEC10A →	+1.284	+0.866	<.001	<.001	3	6
BRCA	CTSG →	+1.411	+0.816	<.001	.004	3	5
OV	CCL11 →	+1.522	+1.050	<.001	<.001	3	5
HNSC	CD79B →	+0.836	+0.851	.001	<.001	3	5
OV	LGALS12 →	+0.581	+1.043	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,800 associations by consensus.

PRG3 vs CLC — LSCC

Explore this scatter interactively →