PRG3

Across TCGA patient cohorts, PRG3 mutation is significantly associated with the immune_cell of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRG3-associated genes across cancer lineages are pDC, Eosinophils, and Endothelial cells. Each is linked with PRG3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRG3-to-partner and partner-to-PRG3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, pDC grouped by PRG3-low versus PRG3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRG3→partner) and Y-score (partner→PRG3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	pDC →	+0.056	+3.032	.008	.018	3	2
SKCM	Eosinophils →	+0.103	+3.316	<.001	.012	3	1
UCEC	Endothelial cells →	-0.037	-2.313	.024	.035	3	1
UCEC	Epithelial cells →	-0.069	-3.159	.027	.019	3	1
UCEC	Basophils →	+0.170	+2.584	.021	.011	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

pDC by PRG3 expression — UCEC

Explore this box plot interactively →