PRG3

Across TCGA cell cohorts, PRG3 RNA expression is significantly associated with the go_rna of many other GO terms, with 345 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PRG3-associated GO terms across cancer lineages are Response to fluoride, Regulation of vascular associated smooth muscle cell differentiation, and Response to selenium ion. Each is linked with PRG3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRG3-to-partner and partner-to-PRG3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to fluoride grouped by PRG3-low versus PRG3-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRG3→partner) and Y-score (partner→PRG3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Response to fluoride →	+0.094	+0.416	<.001	.004	3	2
BLOOD_Leukemia	Regulation of vascular associated smooth muscle cell differentiation →	+0.074	+0.354	<.001	.005	3	2
BLOOD_Leukemia	Response to selenium ion →	+0.075	+0.340	.003	.007	3	1
BLOOD_Leukemia	Regulation of mitochondrial fusion →	+0.038	+0.316	.005	.008	3	1
BLOOD_Leukemia	Negative regulation of platelet-derived growth factor receptor signaling pathway →	+0.133	+0.324	<.001	.001	2	2
BLOOD_Leukemia	Regulation of collagen catabolic process →	+0.207	+0.373	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 345 associations by consensus.

Response to fluoride by PRG3 expression — BLOOD_Leukemia

Explore this box plot interactively →