PRG3

Across TCGA cell cohorts, PRG3 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PRG3-associated genes across cancer lineages are C9orf92 and OR5G3. Each is linked with PRG3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRG3-to-partner and partner-to-PRG3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C9orf92 grouped by PRG3-low versus PRG3-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRG3→partner) and Y-score (partner→PRG3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	C9orf92 →	+0.393	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	OR5G3 →	+0.027	+4.867	.002	.009	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

C9orf92 by PRG3 expression — BLOOD_Lymphoma

Explore this box plot interactively →