PRF1

Across TCGA patient cohorts, PRF1 protein abundance is significantly associated with the RNA expression of many other genes, with 8,359 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PRF1-associated genes across cancer lineages are GZMB, C11orf21, and BIN2. Each is linked with PRF1 in more than 5 cancer types. Because this analysis shows association rather than direction, both PRF1-to-partner and partner-to-PRF1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PRF1 versus GZMB in UCEC, with a Pearson correlation of 0.50.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRF1→partner) and Y-score (partner→PRF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GZMB →	+1.611	+0.519	<.001	.002	3	6
BRCA	C11orf21 →	+0.796	+0.501	<.001	<.001	3	6
UCEC	BIN2 →	+1.104	+0.640	.001	<.001	3	6
HNSC	GNLY →	+1.228	+0.648	<.001	<.001	3	6
HNSC	CD244 →	+1.086	+0.770	<.001	<.001	3	6
GBM	LILRB2 →	+1.496	+0.929	<.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,359 associations by consensus.

PRF1 vs GZMB — UCEC

Explore this scatter interactively →