PREX2

Across TCGA patient cohorts, PREX2 RNA expression is significantly associated with the protein abundance of many other proteins, with 18,785 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible PREX2-associated proteins across cancer lineages are DDX21_S121, SORBS3, and TLN2. Each is linked with PREX2 in more than 6 cancer types. Because this analysis shows association rather than direction, both PREX2-to-partner and partner-to-PREX2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PREX2 versus DDX21_S121 in BRCA, with a Pearson correlation of -0.28.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PREX2→partner) and Y-score (partner→PREX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DDX21_S121 →	-0.744	-0.541	<.001	.009	3	7
BRCA	SORBS3 →	+0.321	+0.798	<.001	<.001	3	7
HNSC	TLN2 →	+0.577	+0.744	<.001	<.001	3	7
COAD	PPP1R12C →	+0.390	+0.454	<.001	.008	3	7
BRCA	RPL5 →	-0.237	-0.790	<.001	<.001	3	6
BRCA	RPS2 →	-0.298	-1.155	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,785 associations by consensus.

PREX2 vs DDX21_S121 — BRCA

Explore this scatter interactively →