PREX2

Across TCGA pan-cancer cohorts, PREX2 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated PREX2 data layer compared with 5 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher PREX2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PREX2 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCS show a favorable association.

KIRP, HNSC, and UVM are the cancer types where PREX2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Tertile	II,III,IV	0.270	0.742	<.001	115	view →
HNSC	DFS	Quartile	All	0.776	0.593	<.001	78	view →
UVM	DFS	Quartile	II,III,IV	0.402	0.896	<.001	73	view →
UCS	OS	Tertile	IV	0.844	0.228	.024	36	view →
BLCA	OS	Quartile	All	0.327	0.738	.003	29	view →
LUSC	DFS	Quartile	All	0.282	0.503	.005	27	view →
SCLC	DFS	Median	II,III,IV	0.833	0.190	<.001	22	view →
STAD	DFS	Quartile	All	0.464	0.595	.015	19	view →
LUAD	DFS	Tertile	II,III,IV	0.528	0.184	.024	16	view →
BRCA	DFS	Tertile	III,IV	0.861	0.733	.010	15	view →
THYM	DFS	Tertile	All	1.000	0.675	.013	9	view →
MESO	OS	Median	IV	0.251	0.578	.039	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

PREX2–KIRP (OS)

Open the KIRP breakdown →