PREX2

Across TCGA patient cohorts, PREX2 mutation is significantly associated with the total protein of many other genes, with 74 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PREX2-associated genes across cancer lineages are STAT3_pY705, C-Raf, and FASN. Each is linked with PREX2 in more than 4 cancer types. Because this analysis shows association rather than direction, both PREX2-to-partner and partner-to-PREX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by PREX2-low versus PREX2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PREX2→partner) and Y-score (partner→PREX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.377	-1.864	<.001	.002	3	5
UCEC	C-Raf →	+0.129	+1.321	.002	.027	3	5
STAD	FASN →	+0.360	+2.015	.014	.016	3	4
STAD	PCNA →	+0.357	+2.502	<.001	.001	3	4
COAD	Caspase-7-cleavedD198 →	+0.859	+2.222	<.001	.009	3	4
STAD	Cyclin-E1 →	+0.436	+3.716	.013	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 74 associations by consensus.

STAT3_pY705 by PREX2 expression — UCEC

Explore this box plot interactively →