PREX2

Across TCGA cell cohorts, PREX2 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,255 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible PREX2-associated GO terms across cancer lineages are Cytoplasmic translational initiation, Regulation of apoptotic signaling pathway, and Cellular response to amino acid starvation. Each is linked with PREX2 in more than 3 cancer types. Because this analysis shows association rather than direction, both PREX2-to-partner and partner-to-PREX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cytoplasmic translational initiation grouped by PREX2-low versus PREX2-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PREX2→partner) and Y-score (partner→PREX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Cytoplasmic translational initiation →	+0.073	+1.361	.002	.002	3	4
KIDNEY	Regulation of apoptotic signaling pathway →	+0.041	+1.865	.001	<.001	3	4
OVARY	Cellular response to amino acid starvation →	+0.062	+1.481	.002	<.001	3	4
LUNG_SCLC	Regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum →	-0.129	-1.049	.001	.003	3	4
OVARY	DCMP metabolic process →	-0.160	-1.303	.001	.005	3	4
OVARY	DCMP catabolic process →	-0.160	-1.303	.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,255 associations by consensus.

Cytoplasmic translational initiation by PREX2 expression — LUNG_SCLC

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