PREX2

Across TCGA cell cohorts, PREX2 mutation is significantly associated with the RNA expression of many other genes, with 733 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PREX2-associated genes across cancer lineages are PLAA, FAM71E2, and KASH5. Each is linked with PREX2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PREX2-to-partner and partner-to-PREX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PLAA grouped by PREX2-low versus PREX2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PREX2→partner) and Y-score (partner→PREX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PLAA →	+0.421	+3.169	.003	.006	3	3
BONE	FAM71E2 →	+0.026	+4.672	<.001	.001	3	2
PANCREAS	KASH5 →	+0.218	+3.807	<.001	.001	3	2
LUNG_NSCLC_LUSC	OR9A2 →	+0.059	+4.137	<.001	.001	3	2
BLOOD_Lymphoma	SERPINA12 →	+0.177	+2.247	.002	.006	3	2
BLOOD_Lymphoma	ACTBL2 →	+0.017	+2.415	.004	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 733 associations by consensus.

PLAA by PREX2 expression — LARGE_INTESTINE

Explore this box plot interactively →