Across TCGA patient cohorts, PRELP mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRELP-associated genes across cancer lineages are ERK2, FoxM1, and STAT3_pY705. Each is linked with PRELP in more than 1 cancer types. Because this analysis shows association rather than direction, both PRELP-to-partner and partner-to-PRELP results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRELP→partner) and Y-score (partner→PRELP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.180	+1.874	.009	.049	3	2
UCEC	FoxM1 →	+0.215	+1.584	.021	.019	3	2
UCEC	STAT3_pY705 →	-0.322	-1.797	<.001	.025	3	2
UCEC	ATM →	-0.482	-2.222	.003	.010	3	2
UCEC	4E-BP1 →	+0.237	+3.321	.015	.009	3	2
UCEC	EGFR_pY1068 →	-0.216	-2.000	.016	.029	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Exploration

PRELP survival (RNA) · tumor vs normal (RNA) · all PRELP data types