Across TCGA pan-cancer cohorts, PRELP RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of PRELP’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where PRELP RNA is repressed in tumor relative to normal tissue. In most cancer types PRELP is over-expressed in tumor, although a few such as BLCA and KICH show the opposite, repressed pattern.

BLCA, KICH, and KIRC are the cancer types where PRELP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PRELP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	III,IV	−5.268	<.001	11	view →
KICH	Male	All	−3.714	<.001	11	view →
KIRC	Male	II,III,IV	−2.038	<.001	11	view →
COAD	Female	II,III,IV	−2.625	<.001	10	view →
THCA	Female	II,III,IV	−2.477	<.001	10	view →
LUAD	Male	All	−1.628	<.001	8	view →
HNSC	Male	All	−1.354	.001	8	view →
LUSC	Male	All	−2.340	<.001	7	view →
UCEC	All	III,IV	−5.300	<.001	6	view →
BRCA	All	II,III,IV	−2.115	<.001	6	view →
READ	All	All	−3.000	<.001	5	view →
STAD	All	All	−1.810	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

Exploration

Same gene, other analysis: PRELP RNA expression & survival · all PRELP data types