PREB

Across TCGA pan-cancer cohorts, PREB mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PREB data layer compared with 29 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher PREB mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PREB expression acts as an unfavorable survival marker, although some lineages such as PDAC and COAD show a favorable association.

LUAD, PDAC, and LSCC are the cancer types where PREB mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	II,III,IV	0.430	0.785	.007	10	view →
PDAC	OS	Median	II,III,IV	0.439	0.278	.009	9	view →
LSCC	DFS	Tertile	III,IV	0.673	1.000	.008	8	view →
COAD	DFS	Median	III,IV	1.000	0.898	.043	6	view →
CCRCC	OS	Tertile	All	0.767	1.000	.045	3	view →
HNSC	DFS	Median	II,III,IV	0.910	0.963	.045	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PREB–LUAD (OS)

Open the LUAD breakdown →