PREB

Across TCGA pan-cancer cohorts, PREB RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of PREB’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PREB RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PREB is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, COAD, and BLCA are the cancer types where PREB tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PREB RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.462	<.001	12	view →
COAD	Female	II,III,IV	+1.180	<.001	11	view →
BLCA	Female	All	+0.976	<.001	11	view →
KIRC	Female	All	+0.461	<.001	11	view →
THCA	Male	III,IV	−0.647	<.001	10	view →
LIHC	Male	II,III,IV	+1.395	<.001	9	view →
LUAD	All	III,IV	+0.806	<.001	9	view →
KICH	Female	II,III,IV	−0.939	<.001	8	view →
LUSC	Female	II,III,IV	+0.931	<.001	8	view →
STAD	All	II,III,IV	+0.914	<.001	8	view →
BRCA	All	All	+0.240	<.001	8	view →
READ	All	II,III,IV	+1.217	.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

PREB–HNSC

Open the HNSC breakdown →