PRDX5

Across TCGA patient cohorts, PRDX5 mutation is significantly associated with the RNA expression of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRDX5-associated genes across cancer lineages are SPDYE2B, MIR548AG2, and GOLGA6C. Each is linked with PRDX5 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRDX5-to-partner and partner-to-PRDX5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPDYE2B grouped by PRDX5-low versus PRDX5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRDX5→partner) and Y-score (partner→PRDX5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SPDYE2B →	+0.098	+3.001	<.001	.009	3	1
BRCA	MIR548AG2 →	+0.509	+5.540	.002	.004	3	1
BRCA	GOLGA6C →	+0.027	+5.096	<.001	.008	3	1
BRCA	FTH1P14 →	+0.194	+5.610	<.001	.004	3	1
BRCA	RNU6-754P →	+0.168	+7.471	<.001	.008	3	1
BRCA	LRRFIP2P1 →	+0.041	+6.950	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

SPDYE2B by PRDX5 expression — UCEC

Explore this box plot interactively →