PRDX1

Across TCGA patient cohorts, PRDX1 mutation is significantly associated with the RNA expression of many other genes, with 61 significant associations in total. BLCA shows the largest number of these associations.

The most reproducible PRDX1-associated genes across cancer lineages are RN7SL656P, RNU6-992P, and LINC02509. Each is linked with PRDX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRDX1-to-partner and partner-to-PRDX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL656P grouped by PRDX1-low versus PRDX1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRDX1→partner) and Y-score (partner→PRDX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RN7SL656P →	+0.099	+5.444	<.001	.002	3	2
UCEC	RNU6-992P →	+0.213	+4.555	<.001	.005	3	2
UCEC	LINC02509 →	+0.051	+4.923	<.001	.002	3	2
SKCM	RNU6-643P →	+0.312	+7.816	<.001	.008	3	1
SKCM	RNU6-456P →	+0.313	+7.816	<.001	.008	3	1
SKCM	MIR544A →	+0.357	+7.816	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 61 associations by consensus.

RN7SL656P by PRDX1 expression — BLCA

Explore this box plot interactively →