PRDM8

Across TCGA patient cohorts, PRDM8 mutation is significantly associated with the RNA expression of many other genes, with 2,856 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRDM8-associated genes across cancer lineages are OR51C1P, LINC00708, and RNA5SP423. Each is linked with PRDM8 in more than 2 cancer types. Because this analysis shows association rather than direction, both PRDM8-to-partner and partner-to-PRDM8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR51C1P grouped by PRDM8-low versus PRDM8-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRDM8→partner) and Y-score (partner→PRDM8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	OR51C1P →	+0.448	+5.093	<.001	.008	3	3
LUSC	LINC00708 →	+0.377	+6.081	<.001	.002	3	3
LUSC	RNA5SP423 →	+0.903	+6.733	<.001	<.001	3	3
THCA	IGHD1-20 →	+1.152	+5.250	<.001	.006	3	2
BRCA	KRTAP19-10P →	+0.179	+9.057	<.001	.003	3	2
BLCA	MTCO2P3 →	+0.079	+7.640	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,856 associations by consensus.

OR51C1P by PRDM8 expression — LUSC

Explore this box plot interactively →