PRDM8

Across TCGA patient cohorts, PRDM8 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRDM8-associated genes across cancer lineages are ASNS, Di-Ras3, and 14-3-3_beta. Each is linked with PRDM8 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRDM8-to-partner and partner-to-PRDM8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by PRDM8-low versus PRDM8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRDM8→partner) and Y-score (partner→PRDM8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.332	+1.415	.014	.046	3	2
UCEC	Di-Ras3 →	-0.290	-3.321	<.001	<.001	3	2
UCEC	14-3-3_beta →	-0.150	-3.780	<.001	<.001	3	1
UCEC	eEF2 →	+0.318	+1.415	.017	.046	3	1
UCEC	EGFR_pY1068 →	-0.222	-1.807	.018	.025	3	1
UCEC	eIF4G →	+0.353	+3.700	.002	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

ASNS by PRDM8 expression — UCEC

Explore this box plot interactively →