PRDM8

Across TCGA cell cohorts, PRDM8 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible PRDM8-associated genes across cancer lineages are OR10C1 and KRTAP7-1. Each is linked with PRDM8 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRDM8-to-partner and partner-to-PRDM8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10C1 grouped by PRDM8-low versus PRDM8-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRDM8→partner) and Y-score (partner→PRDM8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	OR10C1 →	+0.005	+4.807	<.001	.003	3	1
OVARY	KRTAP7-1 →	+0.162	+4.228	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

OR10C1 by PRDM8 expression — OVARY

Explore this box plot interactively →