PRDM7

Across TCGA patient cohorts, PRDM7 protein abundance is significantly associated with the RNA expression of many other genes, with 681 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PRDM7-associated genes across cancer lineages are AKIRIN1P2, NIT2, and NENF. Each is linked with PRDM7 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRDM7-to-partner and partner-to-PRDM7 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PRDM7 versus AKIRIN1P2 in LSCC, with a Pearson correlation of 0.59.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRDM7→partner) and Y-score (partner→PRDM7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	AKIRIN1P2 →	+0.614	+0.661	.001	.002	3	2
BRCA	NIT2 →	+0.544	+0.503	<.001	.007	3	1
BRCA	NENF →	+0.789	+0.448	.003	.007	3	1
BRCA	AREL1 →	-0.336	-0.585	.003	.001	3	1
BRCA	AVPI1 →	+1.054	+0.579	.004	.006	3	1
BRCA	BCL11B →	-1.361	-0.825	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 681 associations by consensus.

PRDM7 vs AKIRIN1P2 — LSCC

Explore this scatter interactively →